Skullcap is one of the most widely used herbs for anxiety and nervous conditions. It is a traditional herb used for soothing a frazzled nervous system and appears to work via the GABAergic system, often through an interaction with the benzodiazepine site on GABAA receptors for its anxiolytic (assist with anxiety) activities. Also Skullcap has demonstrated neuroprotective qualities via significant antioxidant and anti-inflammatory actions (lohani et al, 2013).
A recent placebo-controlled, double-blind crossover study involving 43 healthy volunteers consuming 350 mg of Skullcap in a capsule three times a day for a period of two weeks found this intervention to significantly enhance global mood without reducing energy or cognition involving 19 healthy subjects obtained similar outcomes, noting a significant reduction in perceived anxiety without impairment of intellect or vitality (Wolfson & Hoffmann, 2003).
In clinic Skullcap is used to treat:
- Nervous excitability, restlessness, wakefulness, anxiety
- Physical or mental tiredness
- Headache, depression